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A Simple Blood Test Could Help Catch Pancreatic Cancer Early

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Development and Prospective Validation of a Cell-free DNA-Based Model for the Early Detection of Pancreatic Cancer.DOI 10.11582159-8290.CD-25-0323

Pancreatic cancer is often found too late, when it’s harder to treat. But researchers have now developed a new, noninvasive blood test that could help find this cancer much earlier—sometimes even before symptoms appear.

The test looks at tiny pieces of DNA floating in the blood, known as “cell-free DNA” (cfDNA). In this study, researchers tested the new model on over 460 people—some with pancreatic cancer and some without—and then validated it in a larger group of nearly 2,000 people with diabetes or obesity, who are at higher risk.

The results were promising. The test correctly identified 75% of pancreatic cancer cases, including all patients with the earliest form of the disease (stage 0). In some people, it spotted signs of cancer up to 10 months before they were officially diagnosed. It even performed better than the commonly used CA19-9 blood marker.

The test also helped tell the difference between harmless and risky pancreatic cysts.

This could help doctors decide who needs further testing or early treatment.

This research offers hope for a future where pancreatic cancer can be caught early through a simple blood draw—giving patients a better chance at survival. More large-scale studies are still needed, but the outlook is encouraging.

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Dr. Harsh J Shah
Dr Harsh Shah - GI & HPB Oncosurgeon in India
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