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Heated Chemotherapy May Help Prevent Stomach Cancer Spread After Surgery

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Efficacy and safety of sequential hyperthermic intraperitoneal chemotherapy following surgery for pathological T staging 4 gastric cancer.DOI 10.3748wjg.v32.i6.115556

Stomach cancer can sometimes return after surgery, especially when the tumor has grown deeply into the stomach wall. One common place it spreads is the lining of the abdomen, called the peritoneum. Doctors are studying ways to reduce this risk.
A recent study looked at a treatment called HIPEC (hyperthermic intraperitoneal chemotherapy). In this approach, warm chemotherapy is delivered directly into the abdomen after surgery to destroy remaining cancer cells.
Researchers studied 225 patients with advanced stomach cancer (T4 stage) who had their tumors removed. Some patients received standard chemotherapy alone, while others received HIPEC followed by chemotherapy.
The results showed that patients receiving HIPEC had better disease-free survival, meaning the cancer stayed under control longer. After three years, about 69% of patients in the HIPEC group remained cancer-free, compared with about 50% in the chemotherapy-only group.
HIPEC also helped reduce the risk of cancer spreading to the abdominal lining. Importantly, the treatment did not increase serious side effects compared with standard chemotherapy.
Overall survival at three years was similar between the groups, but patients who received HIPEC tended to live longer overall.
These findings suggest that HIPEC after surgery may help prevent recurrence in high-risk stomach cancer patients, offering another strategy to improve long-term outcomes.

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Dr. Harsh J Shah
Dr Harsh Shah - GI & HPB Oncosurgeon in India
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