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Durvalumab With Chemotherapy May Improve Survival in Stomach and Esophagus Cancer

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Durvalumab With Chemotherapy May Improve Survival in Stomach and Esophagus Cancer

Patients with stomach cancer or gastroesophageal junction cancer often receive chemotherapy before and after surgery. The standard treatment, called FLOT, works for many patients, but the cancer still comes back in some cases. Researchers wanted to see if adding an immune-based treatment, durvalumab, could improve outcomes.

Durvalumab is an immunotherapy. It helps the body’s immune system recognize and attack cancer cells. In this study, almost 950 patients were randomly given either FLOT plus durvalumab or FLOT plus a placebo. Patients took treatment before and after surgery, and some continued durvalumab for longer.

The results were promising. After two years, about 67 out of 100 patients in the durvalumab group were alive without their cancer returning, compared to about 59 out of 100 in the group that did not get durvalumab. Overall survival was also higher in the durvalumab group. Importantly, more patients who received durvalumab had no signs of cancer left in the removed tissue after surgery. This means the cancer responded better to treatment.

The side effects were similar in both groups. Serious side effects happened in about 7 out of 10 patients in each group, showing that adding durvalumab did not make treatment harder to tolerate. Surgery delays and recovery were also similar.

This study shows that adding durvalumab to standard chemotherapy may improve survival and help more patients live cancer-free after surgery. It could become a new option for people with stomach or gastroesophageal junction cancer in the future.

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Dr. Harsh J Shah

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Dr Harsh Shah - GI & HPB Oncosurgeon in India
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