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How Ulcerative Colitis With Liver Inflammation Affects Children’s Long-Term Health

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Prognosis of pediatric-onset inflammatory bowel disease associated with primary sclerosing cholangitis A population-based study DOI- 10.1002jpn3.70176

Inflammatory bowel disease (IBD) in children can be serious. Some children with IBD also develop a liver condition called primary sclerosing cholangitis (PSC). This study looked at how having both IBD and PSC affects a child’s long-term health.

Researchers followed children from one of the largest IBD studies in the world. They compared 24 children with IBD and PSC to 96 children with IBD but no liver problems. All of them were diagnosed before age 18 and followed for at least 2 years.

The study found that both groups of children had similar treatments, including medicines like steroids and immune blockers. They also needed surgery at similar rates. But the big difference came later.

Children with both IBD and PSC had a much higher chance of developing cancer—about 28 times more than expected. They were also 13 times more likely to die compared to children in the general population. This risk was not seen in children with IBD alone.

Even though their bowel disease was managed similarly, having PSC changed the overall outcome.

If your child has both IBD and PSC, regular checkups and careful monitoring are important. Early detection of problems can make a big difference.

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Dr. Harsh J Shah

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Dr Harsh Shah - GI & HPB Oncosurgeon in India
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