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Fatty Liver Disease May Raise Risk of Colon Cancer and Polyps

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Fatty Liver Disease May Raise Risk of Colon Cancer and Polyps

A major new study looked at how fatty liver disease might affect colon health. The results show a strong link between fatty liver and a higher chance of colon problems like polyps, adenomas, and even cancer.

Fatty liver disease is now called NAFLD or MAFLD. It affects over 30% of people worldwide. Most people don’t know they have it. But this liver condition can lead to other serious problems outside the liver, including in the colon.

Researchers reviewed data from over 56 million people. They found that people with fatty liver disease were more likely to have colon polyps, which are small growths that can turn into cancer. They also had a higher risk of adenomas (a type of pre-cancer), hyperplastic polyps, and colorectal cancer.

The study also found that people who were lean (not overweight) but still had fatty liver were at even greater risk of colon adenomas than those who were overweight. This means even if you’re thin, fatty liver disease can still raise your risk.

These results are clear: people with fatty liver disease should talk to their doctor about getting screened for colon problems earlier. A colonoscopy can find polyps before they turn into cancer. Treating liver disease and making lifestyle changes like eating healthier and staying active can help lower the risks.

If you’ve been told you have fatty liver disease, ask your doctor if colon screening is right for you.

DOI: 10.1016/j.clinre.2025.102652

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Dr. Harsh J Shah