Is there any non-surgical option for gallbladder stone ? Sadly, no. Many patients enquire about medicine for gallbladder stone. When the stones inside the gallbladder are very very small (which is called sludge in medical terminology), it can get dissolved on its own. But, when the stones are well formed, unfortunately they remain in place. There is no technology available for gallbladder stone removal except for removing the entire gallbladder.